Post-Graduation in Infectology and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Eur J Heart Fail. 2010 Aug;12(8):866-73. doi: 10.1093/eurjhf/hfq123.
The effects of exercise training in chronic heart failure are well established, however, they have not been evaluated in Chagas cardiomyopathy (ChC). We sought to determine the effects of exercise training on functional capacity, health-related quality of life (HQoL), and brain natriuretic peptide (BNP) levels in patients with ChC.
This randomized, controlled, single-blind trial included 40 patients with ChC (age 49.5 +/- 7.8 years, 57.5% male) who did not practice regular exercise. All patients were assessed, at baseline and at the end of the study, by exercise test (VO(2) and exercise time), six-minute walk test (6MWT), Goldman Specific Activity Scale (SAS), HQoL, and BNP levels. Patients were randomized to inactive control group (ICG = 19) or exercise training group (ETG = 21). Exercise training group patients underwent 12 weeks of exercise training: walking for up to 30 min (intensity 50-70% HR reserve + HR at rest) and warm-up and cooling-down exercising, three times a week. The data were analysed for delta values (Delta= end - baseline). After intervention, compared with the ICG, the ETG had significant increases in functional parameters including, DeltaVO(2) (6.5 vs. 2.8 mL/kg/min, P = 0.001), Delta exercise time (2.9 vs.1.1 min, P < 0.001), Delta6MWT distance (83.5 vs. 2.0 m, P = 0.001) improved DeltaSAS (8 vs. 1 patient, P = 0.008), and HQoL: Delta domains vitality (7.5 vs. 0 points, P = 0.013), Delta emotional aspects (16.7 vs. 0 points, P = 0.012), and Delta mental health (16.1 vs. 0 points, P = 0.031). There was no difference in BNP levels.
In patients with ChC, exercise training was associated with a major improvement in functional capacity and HQoL without any adverse effects.
运动训练对慢性心力衰竭的疗效已得到充分证实，但尚未在恰加斯心肌病（ChC）中进行评估。我们旨在确定运动训练对 ChC 患者的功能能力、健康相关生活质量（HQoL）和脑钠肽（BNP）水平的影响。
这是一项随机、对照、单盲试验，纳入了 40 名不经常运动的 ChC 患者（年龄 49.5±7.8 岁，57.5%为男性）。所有患者在基线和研究结束时均进行运动试验（VO2 和运动时间）、6 分钟步行试验（6MWT）、戈德曼特定活动量表（SAS）、HQoL 和 BNP 水平评估。患者被随机分为非活动对照组（ICG=19）或运动训练组（ETG=21）。运动训练组患者接受 12 周的运动训练：步行最多 30 分钟（强度为 50-70%HR 储备+休息时的 HR）和热身及冷却运动，每周 3 次。分析数据的差值（Delta=结束-基线）。干预后，与 ICG 相比，ETG 在功能参数方面有显著提高，包括 DeltaVO2（6.5 与 2.8 mL/kg/min，P=0.001）、Delta 运动时间（2.9 与 1.1 分钟，P<0.001）、Delta6MWT 距离（83.5 与 2.0 米，P=0.001）、DeltaSAS（8 与 1 例患者，P=0.008）和 HQoL 方面均有改善：Delta 活力（7.5 与 0 分，P=0.013）、Delta 情绪方面（16.7 与 0 分，P=0.012）和 Delta 心理健康（16.1 与 0 分，P=0.031）。BNP 水平无差异。
在 ChC 患者中，运动训练与功能能力和 HQoL 的显著改善相关，无不良影响。
