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通过铈（IV）介导的环丁醇与无机卤化物的氧化偶联反应合成γ-卤代酮。

Synthesis of gamma-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides.

作者信息

Casey Brian M, Eakin Cynthia A, Flowers Robert A

机构信息

Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

出版信息

Tetrahedron Lett. 2009 Mar 25;50(12):1264-1266. doi: 10.1016/j.tetlet.2008.12.114.

DOI:10.1016/j.tetlet.2008.12.114
PMID:20676239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2912607/
Abstract

A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields.

摘要

已开发出一种直接的方法来合成γ-卤代取代的酮，该方法通过硝酸铈铵引发卤化物向1-取代环丁醇的氧化加成反应来实现。此方法反应时间短，能以良好至优异的产率获得一系列溴代和碘代γ-取代的酮。

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