Harchaoui K E L, Visser M E, Kastelein J J P, Stroes E S, Dallinga-Thie G M
Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands.
Curr Cardiol Rev. 2009 Aug;5(3):216-22. doi: 10.2174/157340309788970315.
In 1996 a meta-analysis was published showing that an increase in plasma triglyceride (TG) levels was associated with an increase in CHD risk, even after adjustment for high density lipoprotein cholesterol (HDL-C) levels. Very recently, two studies were published that further extent the early observation and showed the importance of nonfasting plasma triglyceride (TG) levels in the prediction of risk on coronary heart disease (CHD). In the current review we have summarized all available evidence obtained in clinical studies showing that treatment guidelines should reconsider to include nonfasting TG in their risk assessments as nonfasting TG levels may better predict CVD risk.
1996年发表的一项荟萃分析表明,即使在调整高密度脂蛋白胆固醇(HDL-C)水平之后,血浆甘油三酯(TG)水平升高仍与冠心病风险增加相关。最近,两项研究发表,进一步拓展了早期观察结果,并表明非空腹血浆甘油三酯(TG)水平在预测冠心病(CHD)风险方面的重要性。在本综述中,我们总结了临床研究中获得的所有现有证据,表明治疗指南应重新考虑在风险评估中纳入非空腹TG,因为非空腹TG水平可能能更好地预测心血管疾病(CVD)风险。