口腔颊黏膜黏膜相关淋巴组织淋巴瘤 t（11；18）（q21；q21）染色体易位（A1446-M1150）。

t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.

出版信息

J Cancer Res Clin Oncol. 2010 Nov;136(11):1783-5. doi: 10.1007/s00432-010-0939-z. Epub 2010 Jul 31.

PMID:20676680

Abstract

PURPOSE

The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had the t(11;18)(q21;q21) chromosome translocation.

METHODS

Tumor specimens were examined by light microscopy and immunohistochemistry. To investigate where the present case has API-MALT1 fusion, we used the nested PCR and FISH analysis.

RESULTS

Some colonized lymphoid follicles with mantle zone were observed on low-power field, and centrocyte-like cells and monocytoid B cells were observed on high-power field. Immunohistochemical staining of the tumor was positive for bcl-2, CD20, CD79a, CD43, Lambda, Kappa and was negative for CD10, IgG, IgG4, IgM, cyclin D1, bcl-6, CK (AE1/3), Helicobacter pylori. Using the nested PCR and FISH analysis, present case had the t(11;18)(q21;q21) chromosome translocation (A1446-M1150).

CONCLUSION

We report that MALT lymphoma in buccal mucosa has the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) by using the nested PCR and FISH analysis. This is the first report of the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in the oral cavity.

摘要

目的

t（11；18）（q21；q21）染色体易位在胃黏膜相关淋巴组织（MALT）淋巴瘤中很常见，但在其他部位的 MALT 淋巴瘤中很少见。我们研究了一位 66 岁日本女性右颊黏膜发生 MALT 淋巴瘤的可能性，她患有 t（11；18）（q21；q21）染色体易位。

方法

通过光镜和免疫组织化学检查肿瘤标本。为了研究本病例的 API-MALT1 融合发生的部位，我们使用了巢式 PCR 和 FISH 分析。

结果

在低倍镜下观察到一些有套区的淋巴滤泡，在高倍镜下观察到中心细胞样细胞和单核样 B 细胞。肿瘤的免疫组织化学染色 bcl-2、CD20、CD79a、CD43、Lambda、Kappa 阳性，CD10、IgG、IgG4、IgM、cyclin D1、bcl-6、CK（AE1/3）、幽门螺杆菌阴性。使用巢式 PCR 和 FISH 分析，本病例存在 t（11；18）（q21；q21）染色体易位（A1446-M1150）。