Pandolfo N, Spigno L, Guiddo G, Tronfi G, Villavecchia G, Mattioli F P
Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Genova.
Minerva Chir. 1991 Apr 15;46(7 Suppl):253-62.
Increased survival rates after esophagectomy for cancer and the significant development of forms of therapy alternate to surgical treatment, today compel surgeons to devote far more attention to the methods will pursue in reconstructing the alimentary tract after removal of the esophagus. Nine patients with esophago-gastro-plasty and 6 with esophago-jejuno-plasty, after esophagectomy for cancer, experienced a study of esophageal function. The study consisted of extended esophago-gastro-intestinal manometry, performed both while at digestive rest after a semi-solid meal, and of scintigraphy, performed to investigate gastric emptying. 24-hours esophago-gastric pH-metry was also executed, along with basal and stimulated acidity metering in, patients with gastroplasty. The fundamental alterations, from the manometric point of view in esophago-gastro-plasty, are the absence of phase III of the IMMC interdigestively and in the absence of a motor response when ingesting the meal. Scintigraphically this coincides with a fundamental alteration of gastric tubule emptying. On the contrary, in jejunoplasty the jejunal loop retains adequate motility, both during the interdigestive phase and following a meal. Such strikingly diverse motor behavior explains the higher quality of life of patients with jejunoplasty versus patients in whom the stomach is used to substitute for the esophagus.
食管癌切除术后生存率的提高以及手术治疗替代疗法的显著发展,如今促使外科医生更加关注食管切除术后消化道重建所采用的方法。对9例行食管胃成形术和6例行食管空肠成形术的癌症患者在食管癌切除术后进行了食管功能研究。该研究包括在半固体餐后消化休息时进行的扩展食管胃肠测压,以及用于研究胃排空的闪烁扫描。还对行胃成形术的患者进行了24小时食管胃pH值测定,以及基础胃酸度和刺激胃酸度测定。从测压角度来看,食管胃成形术的基本改变是消化间期移行性复合运动(IMMC)的第三相缺失,以及进食时无运动反应。闪烁扫描显示这与胃小管排空的基本改变一致。相反,在空肠成形术中,空肠袢在消化间期和进食后均保持足够的运动性。这种明显不同的运动行为解释了行空肠成形术患者的生活质量高于用胃替代食管的患者。