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[自身免疫性甲状腺炎(桥本甲状腺炎):当前的诊断与治疗]

[Autoimmune thyroiditis (Hashimoto's thyroiditis): current diagnostics and therapy].

作者信息

Fink Heike, Hintze Gerhard

机构信息

Medizinische Klinik, Asklepios Klinik Bad Oldesloe, Bad Oldesloe, Germany.

出版信息

Med Klin (Munich). 2010 Jul;105(7):485-93. doi: 10.1007/s00063-010-1082-y.

Abstract

Hashimoto's thyroiditis is a common autoimmune thyroid disease with preference of female gender. The chronic thyroiditis is characterized by autoantibodies against thyroid peroxidase and thyroglobulin. With manifestation, there is often a subclinical hypothyroidism that finally progresses to a persistent hypothyroidism with typical clinical symptoms and the need of hormonal substitution in succession of the lymphocytic infiltration of the thyroid. The ultrasound of the thyroid shows a hypoechogenic and inhomogeneous parenchyma. Autoimmune thyroiditis is frequently associated with autoimmune disease of other organs, such as vitiligo, Addison's disease, diabetes mellitus type 1, often in the sense of polyglandular syndrome 2.

摘要

桥本甲状腺炎是一种常见的自身免疫性甲状腺疾病,女性更为多发。这种慢性甲状腺炎的特征是存在针对甲状腺过氧化物酶和甲状腺球蛋白的自身抗体。其临床表现通常为亚临床甲状腺功能减退,最终发展为持续性甲状腺功能减退,并伴有典型临床症状,且随着甲状腺淋巴细胞浸润,需要相继进行激素替代治疗。甲状腺超声显示实质回声减低且不均匀。自身免疫性甲状腺炎常与其他器官的自身免疫性疾病相关,如白癜风、艾迪生病、1型糖尿病,通常属于多腺体综合征2型。

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