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改良布莱洛克-陶西格分流术后儿童急性分流阻塞的危险因素。

Risk factors for acute shunt blockage in children after modified Blalock-Taussig shunt operations.

作者信息

Gedicke Malenke, Morgan Gareth, Parry Andrew, Martin Rob, Tulloh Rob

机构信息

Bristol Congenital Heart Centre, Bristol Royal Hospital for Children, UK.

出版信息

Heart Vessels. 2010 Sep;25(5):405-9. doi: 10.1007/s00380-009-1219-1. Epub 2010 Jul 31.

Abstract

Factors relating to acute blockage of modified Blalock-Taussig shunts (MBTS) have not been well described in the literature. Our aim was to determine the outcomes in patients early after undergoing MBTS operations and to identify potential risk factors for acute shunt blockage in the early postoperative period. A retrospective study was performed in a tertiary referral congenital cardiac unit. All children who underwent first shunt insertion for cyanotic congenital heart disease during the study period from 2002 to 2006 were included. Seventy-six children underwent first shunt insertion with a median age of 37 days (range 2 days-8 years) and median weight of 3.75 kg (range 2.1-17.2 kg). The shunt sizes varied from 3 to 6 mm. The rate of acute shunt blockage was 11.8% (9/76), all within the first 24 h. There were 3 early deaths (3.9%), none of which were associated with shunt blockage. The main risk factors for blockage were preoperative high hemoglobin, weight less than 3 kg, and duct patency on echocardiogram after surgery. This study identifies that high preoperative hemoglobin, a weight less than 3 kg at operation, and the presence of a patent duct are statistically significant risk factors for shunt blockage in the acute postoperative period. Further work is needed to determine if reduction in preoperative hemoglobin concentration and attempts to reduce postoperative ductal patency may alter the outcome.

摘要

与改良布莱洛克 - 陶西格分流术(MBTS)急性堵塞相关的因素在文献中尚未得到充分描述。我们的目的是确定接受MBTS手术早期患者的预后情况,并识别术后早期急性分流堵塞的潜在风险因素。在一家三级转诊先天性心脏病治疗中心进行了一项回顾性研究。纳入了2002年至2006年研究期间所有因青紫型先天性心脏病首次进行分流术的儿童。76名儿童接受了首次分流术,中位年龄为37天(范围2天至8岁),中位体重为3.75千克(范围2.1至17.2千克)。分流管尺寸从3毫米到6毫米不等。急性分流堵塞发生率为11.8%(9/76),均发生在术后24小时内。有3例早期死亡(3.9%),均与分流堵塞无关。堵塞的主要风险因素为术前血红蛋白水平高、体重小于3千克以及术后超声心动图显示动脉导管通畅。本研究表明,术前血红蛋白水平高、手术时体重小于3千克以及动脉导管未闭在统计学上是术后早期分流堵塞的显著风险因素。需要进一步研究以确定降低术前血红蛋白浓度以及尝试降低术后动脉导管通畅性是否会改变预后。

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