Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom.
Magn Reson Med. 2010 Dec;64(6):1838-42. doi: 10.1002/mrm.22571.
Inhaled oxygen can be used as a contrast agent for magnetic resonance imaging, due to the T(1) shortening effect of the oxygen dissolved in blood and tissue water. In this study, blood T(1) was measured dynamically in 14 volunteers (seven smokers, seven never-smokers) as the inhaled gas was switched from medical air to 100% oxygen and back to medical air. These T(1) values were converted to changes in partial pressure of oxygen, which were found to be in agreement with literature values. There were differences in curve shape and curve height between the smoker and never-smoker groups, suggesting differences in lung function due to smoking-related damage. These curves could be used as an input function for modeling of oxygen uptake in tissues. The differences between groups highlight the importance of measuring such an input function for each individual rather than relying on an assumed measurement.
吸入氧气可用作磁共振成像的对比剂，这是由于溶解在血液和组织水中的氧产生 T(1)缩短效应。在这项研究中，14 名志愿者（7 名吸烟者，7 名从不吸烟者）的血液 T(1)被动态测量，当吸入气体从医用空气切换到 100%氧气，然后再切换回医用空气时。这些 T(1)值被转换为氧分压的变化，发现与文献值一致。吸烟者和不吸烟者组之间的曲线形状和曲线高度存在差异，这表明由于吸烟相关损伤导致的肺功能差异。这些曲线可用作组织中氧气摄取模型的输入函数。组间差异突出了测量这种输入函数对于每个个体的重要性，而不是依赖于假设的测量。
