Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg im Breisgau, Germany.
Magn Reson Med. 2010 Nov;64(5):1453-60. doi: 10.1002/mrm.22543.
T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.
在慢性左心室心肌梗死的猪模型中，定量测量了 T1ρ弛豫时间。结果发现，在低自旋锁定幅度和 T2 加权图像中，存在低频弛豫机制来抑制内源性对比。中等幅度的自旋锁定脉冲可以克服这些弛豫机制。在一系列射频场幅度下测量了弛豫弥散数据，并建立了一个模型，包括由分子旋转调制的偶极-偶极弛豫和一个明显的交换机制。这些技术可能在临床上用于观察慢性左心室心脏重构。
