Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ 85259, USA.
J Clin Gastroenterol. 2011 Feb;45(2):100-6. doi: 10.1097/MCG.0b013e3181e5d32a.
To evaluate the variation in tolerance to wireless pH-metry compared with catheter-based pH-metry, and to determine clinical characteristics that might predict reduced tolerance to wireless pH-metry.
Consecutive outpatients (n=341) completing wireless (n=234) or catheter-based pH-metry (n=106) were evaluated. All patients completed the pH-Metry Impact Scale and the pH-Metry Symptoms Scale to assess the impact of the pH-metry on activities of daily living and pH-metry associated changes in study-related symptoms. All data are presented as mean (SD) or odds ratios (95% confidence interval).
The impact of pH-metry on activities of daily living were modest, but wireless pH-metry had less impact than catheter-based pH-metry (P=0.01). A sense of foreign body in the chest, chest discomfort, and chest pain were reported more frequently during wireless pH-metry. Difficulty swallowing and painful swallowing were more common during catheter-based pH-metry. Noncardiac chest pain was associated with increased symptom severity. Patients with poor tolerance were twice as likely to have a diagnosis of noncardiac chest pain (odds ratio=2. 53; 95% confidence interval, 1.4-4.6).
Wireless pH-metry has less of an impact on activities of daily living but is not associated with fewer study-related symptoms compared with catheter-based pH-metry. The prevalence of specific study-related symptoms does differ between the 2 groups and noncardiac chest pain seems to be the primary risk factor for more severe study-related symptoms and reduced tolerance for wireless pH-metry. This information may be useful in helping to decide which patients should undergo the wireless pH-metry or receive additional counseling on procedural expectations.
评估与基于导管的 pH 测量相比，无线 pH 测量的耐受性变化，并确定可能预测对无线 pH 测量耐受性降低的临床特征。
连续评估了完成无线（n=234）或基于导管的 pH 测量（n=106）的门诊患者（n=341）。所有患者均完成了 pH 测量影响量表和 pH 测量症状量表，以评估 pH 测量对日常生活活动的影响以及与 pH 测量相关的研究相关症状变化。所有数据均以平均值（SD）或比值比（95%置信区间）表示。
pH 测量对日常生活活动的影响适中，但无线 pH 测量的影响小于基于导管的 pH 测量（P=0.01）。在无线 pH 测量期间，更多患者报告了胸部异物感、胸部不适和胸痛。在基于导管的 pH 测量期间，更常见的是吞咽困难和吞咽疼痛。非心源性胸痛与症状严重程度增加相关。对治疗不耐受的患者诊断为非心源性胸痛的可能性是两倍（比值比=2.53；95%置信区间，1.4-4.6）。
与基于导管的 pH 测量相比，无线 pH 测量对日常生活活动的影响较小，但与较少的研究相关症状无关。两组之间特定的研究相关症状的发生率确实有所不同，而非心源性胸痛似乎是更严重的研究相关症状和对无线 pH 测量耐受性降低的主要危险因素。这些信息可能有助于决定哪些患者应进行无线 pH 测量或接受有关程序预期的额外咨询。
