Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 404100, China.
BMC Gastroenterol. 2013 Jan 15;13:10. doi: 10.1186/1471-230X-13-10.
Wireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD.
Thirty patients from Department of Gastroenterology of The First Affiliated Hospital of Chongqing Medical University who were suspected GERD underwent JSPH-1 pH capsule. The capsule was placed 5 cm proximal to the squamocolumnar junction (SCJ) by endoscopic determination, the data was recorded consecutively for 48 hours. Then all pH data was downloaded to a computer for analysis. The discomforts reported by patients were recorded.
30 patients were placed JSPH-1 pH capsule successfully and completed 24-hour data recording, 29 patients completed 48-hour data recording. One patient complained of chest pain and required endoscopic removal. No complications and interference of daily activities were reported during data monitoring or follow-up period. 48-hour pH monitoring detected 15 patients of abnormal acid exposure, on day1 detected 9 patients, the difference had statistical significance (P<0.01). Positive symptom index (SI) was identified in 3 patients with normal pH data in both 24-hours. In total, 48-hour monitoring increased diagnosis of GERD in 9 patients.
48-hour esophageal pH monitoring with JSPH-1 wireless pH monitoring system is safe, well tolerated and effective. It can be feasible for clinical application to diagnose GERD.
无线食管 pH 监测系统是诊断胃食管反流病（GERD）的重要方法，本研究旨在测试中国自主研发的首款无线食管 pH 监测系统的耐受性和实用性，评估其用于 GERD 临床诊断的可行性。
重庆医科大学附属第一医院消化内科 30 例疑似 GERD 患者接受 JSPH-1 pH 胶囊检查。胶囊通过内镜确定放置在食管鳞柱状交界处（SCJ）近端 5cm 处，连续记录 48 小时数据。然后将所有 pH 数据下载到计算机进行分析。记录患者报告的不适。
30 例患者成功放置 JSPH-1 pH 胶囊并完成 24 小时数据记录，29 例患者完成 48 小时数据记录。1 例患者诉胸痛，需行内镜取出。在数据监测或随访期间，无并发症和日常活动干扰的报告。48 小时 pH 监测发现 15 例异常酸暴露，第 1 天发现 9 例，差异有统计学意义（P<0.01）。24 小时内 pH 数据正常的 3 例患者出现阳性症状指数（SI）。总的来说，48 小时监测增加了 9 例 GERD 的诊断。
JSPH-1 无线 pH 监测系统 48 小时食管 pH 监测安全、耐受性好、效果好。它可用于 GERD 的临床诊断。
