Salom David, Sanz-Marco Empar, Mullor Jose L, Lopez-Prats Maria Jesus, Garcia-Delpech Salvador, Udaondo Patricia, Millan Jose Maria, Arevalo J Fernando, Diaz-Llopis Manuel
Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain.
Mol Vis. 2010 Jul 29;16:1448-52.
The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU).
A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit.
The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann-Whitney U test, p<0.001). The level of NGAL was 139,197.38+/-183,426.36 (mean+/-SD) pg/ml in eyes with AAU and 3,169.96+/-1,595.78 pg/ml in the eyes of the control group.
The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response.
本研究旨在评估特发性急性前葡萄膜炎（AAU）患者房水中中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的水平。
一项对照研究。收集20例特发性AAU患者20只眼的房水。对照组包括20例即将接受白内障手术且无任何其他眼部或全身性疾病患者的20份房水样本。使用市售ELISA试剂盒测定NGAL水平。
特发性AAU患者房水中NGAL浓度显著高于对照组（曼-惠特尼U检验，p<0.001）。AAU患眼中NGAL水平为139,197.38±183,426.36（均值±标准差）pg/ml，对照组患眼中为3,169.96±1,595.78 pg/ml。
特发性AAU患眼中房水NGAL水平升高。这些结果表明，NGAL与AAU患者炎症调节有关，可作为眼部炎症和免疫调节治疗反应的生物标志物。
