神经质而非ω-3脂肪酸水平与艾司西酞普兰的早期反应相关。
Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram.
作者信息
Fiedorowicz Jess G, Hale Nancy, Spector Arthur A, Coryell William H
机构信息
Departments of Psychiatry and Epidemiology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
出版信息
Ann Clin Psychiatry. 2010 Aug;22(3):157-63.
BACKGROUND
Omega-3 fatty acid (O3FA) levels and dimensional personality measures have been associated with major depression and the course of depressive illness. We sought to study the utility of O3FA levels and dimensional personality measures as predictors of early improvement with escitalopram.
METHODS
Twenty-four participants were enrolled in an open-label trial of escitalopram 10 mg/d for 4 weeks. Baseline erythrocyte O3 levels and dimensional personality assessments were obtained.
RESULTS
Using a conservative, intention-to-treat analysis, baseline neuroticism (r = -0.57; P = .007), as measured by the Revised NEO Personality Inventory but not erythrocyte O3 levels, was correlated with improvements on escitalopram. A facet analysis of the neuroticism domain showed the relationship with antidepressant response to be focused on trait anxiety (r = -0.65; P = .002).
CONCLUSIONS
Anxiety may have important prognostic implications on subsequent response to selective serotonin reuptake inhibitors, such as escitalopram.
背景
ω-3脂肪酸（O3FA）水平和人格维度测量与重度抑郁症及抑郁性疾病的病程有关。我们试图研究O3FA水平和人格维度测量作为艾司西酞普兰早期疗效预测指标的效用。
方法
24名参与者参加了一项为期4周、每日服用10mg艾司西酞普兰的开放标签试验。获取了基线红细胞O3水平和人格维度评估结果。
结果
采用保守的意向性分析，通过修订的大五人格量表测量的基线神经质（r = -0.57；P = .007）与艾司西酞普兰治疗后的改善情况相关，而红细胞O3水平与之无关。对神经质领域的一个方面进行分析显示，与抗抑郁反应的关系主要集中在特质焦虑上（r = -0.65；P = .002）。
结论
焦虑可能对后续对选择性5-羟色胺再摄取抑制剂（如艾司西酞普兰）的反应具有重要的预后意义。
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