Unité de Pharmacologie Chimique et Génétique et Imagerie, CNRS n degrees 8151, Ecole Nationale Supérieure de Chimie de Paris, Chimie ParisTech, Université Paris Descartes, Paris, France.
Phys Chem Chem Phys. 2010 Sep 14;12(34):9976-88. doi: 10.1039/c0cp00271b. Epub 2010 Aug 2.
We present an overview of the successes and challenges still faced in the detection of NO, O(2)(-) and ONOO(-) in biological media. We provide a full discussion on the electrochemical analyses of each of these species and we summarise the significant research contributions towards the development of sensors for individual and simultaneous detection of these species. We emphasize the importance of understanding the potential interferents in developing such sensors. We show that significant advances have been made with regard to the detection of NO in biological media leading to the development of marketable NO sensors, though there is room for improvement in terms of interferences. A brief outlook into the future perspectives of the use of a multi-electrochemical array sensor for simultaneous detection of NO, O(2)(-) and ONOO(-) is presented.
我们介绍了在生物介质中检测 NO、O(2)(-) 和 ONOO(-) 方面的成功和仍然面临的挑战。我们全面讨论了每种物质的电化学分析，并总结了在开发用于单独和同时检测这些物质的传感器方面的重要研究贡献。我们强调了在开发此类传感器时理解潜在干扰物的重要性。我们表明，在检测生物介质中的 NO 方面已经取得了重大进展，导致了市售 NO 传感器的发展，尽管在干扰方面仍有改进的空间。简要展望了使用多电化学阵列传感器同时检测 NO、O(2)(-) 和 ONOO(-) 的未来前景。
