Zhdan-Pushkina S M, Kondrat'eva L D, Avenirova E L, Tarasova L M
Mikrobiologiia. 1978 Jan-Feb;47(1):41-7.
Histones have been found to interfere with the permeability of the cellular membranes of Escherichia coli and Staphylococcus aureus, this resulting in the liberation of 14C-amino acids, the UV-absorbing endogenous material, and the products of RNA degradation. Histones, particularly arginine-rich fractions, stimulated the RNAase activity of the bacteria. Histones inhibited the phosphatase activity of E. coli and stimulated that of Staphylococcus aureus. The ATPase activity of the cells increased upon contact with histones. These enzyme systems are presumed to be components of a mechanism whose activity increases upon the action on the cells of factors interfering with the permeability of the membranes so that low-molecular-weight compounds are liberated from the cells. It is possible that the RNAase, ATPase and phosphatase systems repair the pool of low-molecular-weight compounds, thus contributing to the survival of the bacteria.
已发现组蛋白会干扰大肠杆菌和金黄色葡萄球菌细胞膜的通透性，从而导致14C - 氨基酸、紫外线吸收内源性物质以及RNA降解产物的释放。组蛋白，尤其是富含精氨酸的组分，会刺激细菌的RNA酶活性。组蛋白抑制大肠杆菌的磷酸酶活性，却刺激金黄色葡萄球菌的磷酸酶活性。细胞与组蛋白接触后，其ATP酶活性增强。据推测，这些酶系统是一种机制的组成部分，该机制的活性会因干扰膜通透性的因子作用于细胞而增强，从而使低分子量化合物从细胞中释放出来。RNA酶、ATP酶和磷酸酶系统有可能修复低分子量化合物库，从而有助于细菌存活。
