Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, São Paulo, Brazil.
Mycopathologia. 2011 Feb;171(2):93-101. doi: 10.1007/s11046-010-9351-0. Epub 2010 Jul 31.
Candida yeasts are opportunistic pathogens responsible for infections in immunocompromised individuals. Among the virulence factors present in these yeasts we can mention the ability to adhere to host cells, exoenzyme production and germ tube formation. Several compounds, such as antifungal agents, plants extracts, protein inhibitors and surfactants, have been tested regarding their capacity in inhibit Candida spp. virulence factors. Among these compounds, a significant lower number of works are focused on the inhibition action caused by different types of surfactant. The present work aimed to evaluate the effect generated by the surfactants cetyltrimethylammonium chloride (CTAC), sodium dodecyl sulfate (SDS), N-hexadecyl-N-N'-dimethyl-3-ammonio-1-propane-sulfonate (HPS) and octylphenoxypolyethoxyethanol (Triton X-100) on the viability, adhesion ability and exoenzyme production by Candida species. CTAC and HPS were capable to inhibit Candida spp. growth at very low concentrations. All surfactants demonstrated to be capable to inhibit the adhesion of Candida species to buccal epithelial cells (BEC) and the proteinase production. On the other hand, the phospholipase production remained unaltered after the treatment with these compounds. The present data denote that cationic and zwitterionic surfactants are interesting prototypes of inhibitory agents against Candida spp., which is probably associated with the cationic punctual charge of both surfactants. The results are discussed in details in agreement with recent reports from literature.
念珠菌属酵母菌是机会性病原体，可导致免疫功能低下个体感染。在这些酵母菌中存在的毒力因子包括与宿主细胞黏附的能力、外酶的产生和芽管的形成。已有多种化合物，如抗真菌药物、植物提取物、蛋白抑制剂和表面活性剂，因其抑制念珠菌属毒力因子的能力而被检测。在这些化合物中，仅有少数研究工作集中在不同类型的表面活性剂引起的抑制作用上。本工作旨在评估表面活性剂十六烷基三甲基氯化铵（CTAC）、十二烷基硫酸钠（SDS）、N-十六烷基-N'-N-二甲基-3-氨丙基-1-丙烷磺酸盐（HPS）和辛基酚聚氧乙烯醚（Triton X-100）对念珠菌属物种的活力、黏附能力和外酶产生的影响。CTAC 和 HPS 能够以非常低的浓度抑制念珠菌属的生长。所有表面活性剂均能抑制念珠菌属对口腔上皮细胞（BEC）的黏附以及蛋白酶的产生。另一方面，这些化合物处理后，磷脂酶的产生保持不变。目前的数据表明，阳离子和两性离子表面活性剂是抑制念珠菌属的有前途的抑制剂原型，这可能与两种表面活性剂的阳离子点状电荷有关。结果与文献中的最新报道进行了详细讨论。
