Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China.
Arch Med Res. 2010 Apr;41(3):221-5. doi: 10.1016/j.arcmed.2010.02.011.
Cytokine-mediated immunity plays a crucial role in the pathogenesis of various autoimmune diseases including systemic lupus erythematosus (SLE). The recent identification of the dimeric interleukin (IL)-12-related cytokine IL-23 now contributes to our understanding of the fine-tuning of cellular immunity. The critical implication of IL-12 p40 in autoimmune inflammation has long been misinterpreted and until recently have studies revealed that it is IL-23, not IL-12, is the crucial factor in this immune dysregulation. Therefore, targeting of IL-23 or the IL-23 receptor is a potential therapeutic approach for autoimmune diseases including SLE. In this opinion article, we will discuss the biological features of IL-23 and summarize recent advances on the role of IL-23 in the pathogenesis and treatment of SLE.
细胞因子介导的免疫在各种自身免疫性疾病的发病机制中起着至关重要的作用，包括系统性红斑狼疮 (SLE)。最近发现的二聚体细胞因子白细胞介素 (IL)-12 相关细胞因子 IL-23，有助于我们理解细胞免疫的精细调节。IL-12 p40 在自身免疫炎症中的关键作用长期以来被误解，直到最近的研究才揭示，在这种免疫失调中起关键作用的是 IL-23，而不是 IL-12。因此，针对 IL-23 或 IL-23 受体是治疗包括 SLE 在内的自身免疫性疾病的一种潜在治疗方法。在这篇观点文章中，我们将讨论 IL-23 的生物学特性，并总结最近关于 IL-23 在 SLE 发病机制和治疗中的作用的进展。
