Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Implant Dent. 2010 Aug;19(4):330-41. doi: 10.1097/ID.0b013e3181e59b32.
To document the clinical and histologic outcomes of sinus augmentation using a novel allogenic bone substitute as a sole grafting material.
Patients in need of sinus augmentation before implant placement were recruited for this study. Sinus augmentation procedures were performed following a lateral approach, using a freeze-dried allograft as the only grafting material. Patients were followed up postoperatively for 6 months. Plaque score, wound healing, and patient discomfort were recorded at each follow-up visit. Implants were placed between 6 and 7 months after sinus augmentation and restored 6 months later. Bone core biopsy specimens were harvested at the time of implant placement and processed for histologic and histomorphometrical analysis. Vital bone, remaining allograft (RA) particles, and nonmineralized tissue percentages were assessed on each sample. Results were expressed as mean percentages with SD.
Of the 23 sinus patients, 20 patients underwent sinus augmentation surgery. All patients had satisfactory postoperative healing in the absence of complications. A total of 39 implants were placed. One implant failed and was replaced 3 months later. Histologic analysis revealed the presence of well-organized lamellar bone, in direct contact with RA particles. Mean vital bone was 23.02 +/- 19.11%, mean RA was 22.25 +/- 20.30%, and average nonmineralized tissue was 54.73 +/- 13.51%.
Clinical and histologic findings support the suitability of an allograft consisting of a combination of cortical and cancellous chips for sinus augmentation procedures.
记录使用新型同种异体骨替代物作为唯一移植物进行鼻窦提升的临床和组织学结果。
本研究招募了需要在植入物放置前进行鼻窦提升的患者。鼻窦提升程序采用外侧入路进行，使用冻干同种异体移植物作为唯一的移植物材料。术后 6 个月对患者进行随访。在每次随访时记录菌斑评分、伤口愈合和患者不适。鼻窦提升后 6-7 个月植入物，6 个月后修复。在植入物放置时采集骨芯活检标本，并进行组织学和组织形态计量学分析。评估每个样本中的活骨、剩余同种异体（RA）颗粒和未矿化组织的百分比。结果以平均值和标准差表示。
在 23 名鼻窦患者中，有 20 名患者接受了鼻窦提升手术。所有患者均无并发症，术后愈合良好。共放置 39 个植入物。1 个植入物失败，3 个月后更换。组织学分析显示存在组织良好的板层骨，与 RA 颗粒直接接触。平均活骨为 23.02±19.11%，平均 RA 为 22.25±20.30%，平均未矿化组织为 54.73±13.51%。
临床和组织学发现支持由皮质和松质骨片组成的同种异体移植物用于鼻窦提升程序的适用性。
