Douple E B
Natl Cancer Inst Monogr. 1977 Dec;46:179-84.
Rats bearing intracranial brain tumors were treated with single ip injections of the killed Corynebacterium parvum, a single dose of X-rays, or a combination of both treatments. Animals given injections of 2.6 mg C. parvum 12 days after implantation of the tumor had a median survival time (MST) of 50 days compared with an MST of 44 days for an untreated group. These animals given C. parvum had a 33% increased life-span (ILS) that was significant at the P=0.05 level. Although the MST of animals that received C. parvum 2 days before a tumor X-ray dose of 3,015 rads on day 14 was greater than that of rats given irradiation alone, the ILS of the group administered both treatments was not significant relative to the latter group. The MST of animals that received C. parvum 7 days before irradiation was not different from that of animals given injections of C. parvum 1 day postirradiation.
给患有颅内脑肿瘤的大鼠单次腹腔注射灭活的短小棒状杆菌、单次给予X射线照射，或两种治疗方法联合使用。在肿瘤植入12天后注射2.6mg短小棒状杆菌的动物，其平均生存时间（MST）为50天，而未治疗组的MST为44天。接受短小棒状杆菌治疗的这些动物的寿命延长了33%（ILS），在P = 0.05水平具有显著性。尽管在第14天给予3015拉德肿瘤X射线剂量前2天接受短小棒状杆菌治疗的动物的MST大于仅接受照射的大鼠，但两种治疗联合组的ILS相对于后一组并无显著性差异。在照射前7天接受短小棒状杆菌治疗的动物的MST与照射后1天注射短小棒状杆菌的动物的MST没有差异。
