Kreider J W, Bartlett G L, Purnell D M, Webb S
Cancer Res. 1978 Mar;38(3):689-92.
We studied the effects of intratumor injection of Corynebacterium parvum vaccine on the survival of 13762A tumor-bearing rats. Vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. Although 30 to 40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases ultimately killed one-fourth of the regressors. Rats given 1500 microgram of C. parvum intratumorally at 7 days, with or without later primary tumor excision at 20 days were cured at a rate of 10 to 40%. Repeated injections improved the results (60%). C. parvum injections delayed until 12 and 17 days were ineffective. Cured rats were immune to rechallenge with 13762A tumor.
我们研究了肿瘤内注射短小棒状杆菌疫苗对13762A荷瘤大鼠存活情况的影响。对已形成（7日龄）肿瘤进行疫苗注射可使存活期呈剂量依赖性延长，并治愈了部分动物。尽管30%至40%接受疫苗注射的原发性肿瘤出现消退，但复发和转移灶的持续生长最终导致四分之一肿瘤消退的动物死亡。在第7天肿瘤内注射1500微克短小棒状杆菌的大鼠，无论在第20天是否进行原发性肿瘤切除，治愈率为10%至40%。重复注射可改善结果（60%）。将短小棒状杆菌注射推迟至第12天和第17天则无效。治愈的大鼠对再次接种13762A肿瘤具有免疫力。
