温和且通用的锌醇盐催化酮与烯丙基频哪醇硼酸酯的烯丙基化反应。
Mild and general zinc-alkoxide-catalyzed allylations of ketones with allyl pinacol boronates.
机构信息
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, USA.
出版信息
Org Lett. 2010 Sep 3;12(17):3748-51. doi: 10.1021/ol101301s.
PMID:20684564
Abstract
A general and efficient zinc-alkoxide-catalyzed allylation of a diverse array of ketones with allyl boronates is presented. The methodology is effective with 2 mol % of catalyst and with relatively short reaction times. Studies of the key exchange process are presented, which support a cyclic transition state for the boron to zinc exchange.
摘要
本文报道了一种通用且高效的锌醇盐催化的酮与烯丙基硼酸酯的烯丙基化反应。该方法在 2 mol %催化剂用量和较短的反应时间下都具有很好的效果。本文还对关键的交换过程进行了研究，支持了硼到锌的交换的环状过渡态。
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