Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.
Cancer Lett. 2013 May 28;332(2):206-14. doi: 10.1016/j.canlet.2010.06.013. Epub 2010 Aug 3.
Inhibitor of apoptosis (IAP) proteins play pivotal roles in cellular survival by blocking apoptosis, modulating signal transduction, and affecting cellular proliferation. Through their interactions with inducers and effectors of apoptosis IAP proteins can effectively suppress apoptosis triggered by diverse stimuli including death receptor signaling, irradiation, chemotherapeutic agents, or growth factor withdrawal. Evasion of apoptosis, in part due to the action of IAP proteins, enhances resistance of cancer cells to treatment with chemotherapeutic agents and contributes to tumor progression. Additionally, IAP genes are known to be subject to amplification, mutation, and chromosomal translocation in human malignancies and autoimmune diseases. In this review we will discuss the role of IAP proteins in cancer and the development of antagonists targeting IAP proteins for cancer treatment.
凋亡抑制蛋白（IAP）通过阻断细胞凋亡、调节信号转导和影响细胞增殖，在细胞存活中发挥关键作用。通过与凋亡诱导剂和效应物的相互作用，IAP 蛋白可以有效地抑制多种刺激物（包括死亡受体信号、辐射、化疗药物或生长因子剥夺）触发的细胞凋亡。凋亡的逃逸，部分归因于 IAP 蛋白的作用，增强了癌细胞对化疗药物治疗的抵抗力，并促进了肿瘤的进展。此外，已知 IAP 基因在人类恶性肿瘤和自身免疫性疾病中存在扩增、突变和染色体易位。在这篇综述中，我们将讨论 IAP 蛋白在癌症中的作用，以及针对 IAP 蛋白开发拮抗剂用于癌症治疗的情况。
