Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa.
J Neuropsychiatry Clin Neurosci. 2010 Summer;22(3):313-20. doi: 10.1176/jnp.2010.22.3.313.
Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric symptom. Thirteen HIV+ participants with apathy, 13 HIV+ participants with no apathy, and 10 healthy comparison subjects were examined using diffusion tensor imaging in the region of the anterior cingulate and corpus callosum. Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex.
艾滋病病毒感染者常报告出现冷漠症状。此前尚无研究评估艾滋病病毒感染者的白质与冷漠症状之间的关系。作者旨在确定艾滋病病毒感染者的冷漠症状是否反映了病毒对皮质下脑区的直接影响，还是继发的神经精神症状。采用弥散张量成像技术，对 13 名存在冷漠症状的 HIV 阳性参与者、13 名无冷漠症状的 HIV 阳性参与者和 10 名健康对照者的前扣带回和胼胝体区域进行了检测。该研究的结果证实了假设，即冷漠症状与通过内侧前额叶皮质传递的白质束改变有关。
