Department of Aquaculture Biotechnology, Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurchi, Tamil Nadu, India.
Pharm Biol. 2011 Jan;49(1):73-7. doi: 10.3109/13880209.2010.496086. Epub 2010 Aug 5.
The production of fish is limited by infectious diseases; when a fish grows in an immunosuppressed condition, it becomes highly susceptible to disease.
The present research work investigates immunomodulatory action of Aegle marmelos (Linn.) Corr. Serr. (Rutaceae) in Catla catla Hamilton (Cyprinidae) for enhancing immune protection of the fish against bacterial infections.
Doses of 0, 5, 10, 15, 20, 25 and 30 g aqueous plant leaf extract/kg feed were administered orally to the freshwater fish, Catla catla for a period of 30 days to investigate its efficiency to enhance the non-specific immune responses against the fish pathogen Pseudomonas aeruginosa (Schröter) Migula (Pseudomonadaceae).
The fish were challenged with pathogens through water medium for 30 days and the immunomodulatory effect of the Aegle marmelos was evaluated on the blood samples every 5 days until 15 days after infection. The results obtained from the study shows that the 25 g leaf extract/kg of feed was found to be competent to enhance optimum immune response. The effectiveness of the immunostimulant action was found to be best for the first 5 days after challenging with pathogen and subsequently, the immune response was found to decline in all the concentrations of plant extract.
The results of the study will be helpful for further investigation in the field to improve the immunocompetence of fish against bacterial pathogens.
鱼类的产量受到传染病的限制；当鱼类在免疫抑制的情况下生长时，它极易受到疾病的影响。
本研究调查了酸橙（Aegle marmelos（Linn.）Corr. Serr.（芸香科））对 catla 鱼（Cyprinidae）的免疫调节作用，以增强鱼类对细菌感染的免疫保护。
将 0、5、10、15、20、25 和 30 g 水提植物叶提取物/公斤饲料的剂量口服给予淡水鱼，catla catla，以研究其在 30 天内增强对鱼类病原体铜绿假单胞菌（Schröter）Migula（假单胞菌科）的非特异性免疫反应的效率。
通过水介质对鱼进行了 30 天的挑战，并在感染后 15 天内每 5 天对血液样本进行评估，以评估酸橙的免疫调节作用。研究结果表明，25 g 叶提取物/公斤饲料被发现能够增强最佳免疫反应。免疫刺激剂的作用效果在受到病原体挑战后的前 5 天内最佳，随后在所有植物提取物浓度下，免疫反应均下降。
该研究的结果将有助于进一步在该领域进行研究，以提高鱼类对细菌病原体的免疫能力。
