猪皮肤源性干细胞的多能性。
The multi-potentiality of skin-derived stem cells in pigs.
机构信息
Division of Animal Sciences, University of Missouri, Columbia, MO 65201, USA.
出版信息
Theriogenology. 2011 May;75(8):1372-80. doi: 10.1016/j.theriogenology.2010.06.010. Epub 2010 Aug 5.
Multipotent skin-derived stem cells represent neural-crest derived precursors which have neural and mesodermal potency and can generate neurons, glias, smooth muscle cells, and adipocytes. Transcriptional profiling studies show that both intrinsic programs and extrinsic signaling pathways mediate their neural and mesodermal potency. In addition, recent progress implies that skin-derived stem cells may have a broader developmental potency than previously expected, of which is their potential to generate germline cells in vitro. In this review, we discuss the transcriptional profiling of multipotency and neural crest-derived characteristics of skin-derived stem cells, and argue for their potential germ-line competency in the view of nuclear and cellular reprogramming.
多能皮肤源性干细胞代表神经嵴衍生前体细胞，具有神经和中胚层潜能，可生成神经元、神经胶质细胞、平滑肌细胞和脂肪细胞。转录谱研究表明，内在程序和外在信号通路共同介导其神经和中胚层潜能。此外，最近的进展表明，皮肤源性干细胞的发育潜能可能比之前预期的更广泛，包括它们在体外生成生殖细胞的潜力。在这篇综述中，我们讨论了皮肤源性干细胞的多能性和神经嵴衍生特征的转录谱，并从核和细胞重编程的角度讨论了它们潜在的生殖系能力。
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