Department of Pharmacy, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA.
Am J Health Syst Pharm. 2010 Aug 15;67(16):1351-3. doi: 10.2146/ajhp090348.
A case of angioedema associated with the initiation of a nonsteroidal antiinflammatory drug in a patient stable on an angiotensin-converting-enzyme inhibitor is reported.
A 68-year-old African-American man with no known drug allergies and a history of hypertension, benign prostatic hypertrophy, diverticulosis, and gout arrived at the clinic with swelling of the lips and tongue three days after he started taking naproxen 375 mg every eight hours as needed for pain associated with acute gout. He denied urticaria, difficulty breathing, fever, abdominal pain, vomiting, and diarrhea. His other medications included quinapril 10 mg daily (taken for 5 years), tamsulosin hydrochloride 0.4 mg daily, omeprazole 20 mg daily, and colchicine 0.6 mg daily. He had reported smoking approximately 2.5 packs of cigarettes per week and consuming alcohol (one to two drinks) on the weekends. He denied any illicit drug use, drug rash, or seasonal allergies. Naproxen was discontinued, and the patient was treated with prednisone (tapered regimen) and acetaminophen 650-mg tablets, and his angioedema resolved. The Naranjo et al. probability scale revealed that naproxen and quinapril coadministration was the probable cause of the patient's adverse reaction (score of 7).
A 68-year-old African-American man who had been receiving quinapril for 5 years developed angioedema after initiation of naproxen.
报告一例血管性水肿病例，该病例与血管紧张素转换酶抑制剂稳定的患者开始使用非甾体抗炎药有关。
一名 68 岁非裔美国男性，无已知药物过敏史，有高血压、良性前列腺增生、憩室病和痛风病史。他因急性痛风引起的疼痛，开始每天服用萘普生 375mg，每八小时按需服用，三天后出现嘴唇和舌头肿胀。他否认有荨麻疹、呼吸困难、发热、腹痛、呕吐和腹泻。他的其他药物包括喹那普利 10mg 每天（服用 5 年）、盐酸坦索罗辛 0.4mg 每天、奥美拉唑 20mg 每天和秋水仙碱 0.6mg 每天。他报告每周大约吸 2.5 包香烟，周末饮酒（一到两杯）。他否认使用任何非法药物、药物皮疹或季节性过敏。停用萘普生后，患者接受泼尼松（逐渐减量方案）和对乙酰氨基酚 650mg 片剂治疗，其血管性水肿消退。Naranjo 等概率量表显示，萘普生和喹那普利联合使用是患者不良反应的可能原因（评分 7）。
一名 68 岁非裔美国男性，服用喹那普利 5 年后，在开始使用萘普生后出现血管性水肿。
