Department of Analytical Chemistry, Marie Curie Building (Annex), Campus de Rabanales, University of Cordoba, E-14071 Cordoba, Spain.
Analyst. 2010 Sep;135(9):2220-32. doi: 10.1039/c0an00307g. Epub 2010 Aug 6.
The main objective of this Tutorial Review is to approach the modern principles and practices of Analytical Chemistry to Point-of-Care Testing (POCT) systems in order to contribute to improve both the development of new devices and the reliable application of the existing ones. In this article, after contextualization of the topic, POCT systems (POCTs) are fully defined using several approaches. The requirements of a POCT system to be a robust and reliable tool available to patients and medical workers are described as well as their desirable complementary characteristics. In addition, the technical components of POCTs materialized in the implementation of the steps of the analytical processes (sample introduction, sample processing, visual or instrumental detection, and data processing) are outlined. Besides, analytical properties assigned to POCTs and to their quantitative and qualitative results are highlighted. Special emphasis is given to Quality Assurance and Quality Control procedures, which are essential aspects to achieving reliable results. Finally, decision making based on the results obtained with POCTs is discussed as are their benefits and drawbacks.
本教程综述的主要目的是探讨分析化学的现代原理和实践如何应用于即时检测（POCT）系统，以有助于改进新设备的开发和现有设备的可靠应用。在本文中，首先对该主题进行了背景介绍，然后使用几种方法对 POCT 系统（POCTs）进行了全面定义。描述了 POCT 系统作为一种可供患者和医务人员使用的强大可靠工具的要求，以及其理想的补充特性。此外，POCT 技术组件在分析过程步骤的实施中（样品引入、样品处理、视觉或仪器检测以及数据处理）进行了概述。此外，还强调了分配给 POCT 及其定量和定性结果的分析特性。特别强调了质量保证和质量控制程序，这是获得可靠结果的重要方面。最后，讨论了基于 POCT 获得的结果进行决策的问题，以及它们的优缺点。
