Prata Ndola, Mbaruku Godfrey, Grossman Amy A, Holston Martine, Hsieh Kristina
School of Public Health, University of California, Berkeley, University Hall, Berkeley, CA 94720-7360, USA.
Afr J Reprod Health. 2009 Jun;13(2):117-28.
This paper evaluates the safety and acceptability of long-term community-based use of misoprostol for management of postpartum hemorrhage (PPH) in home-births, by comparing deliveries with and without misoprostol use in communities of Kigoma, Tanzania. We administered a standardized survey instrument to women who delivered between August 2004 and May 2007. 940 women completed questionnaires, corresponding to 950 deliveries. Findings showed that the majority of TBAs administered misoprostol at the correct time (76%). Receipt of three or five tablets was most commonly reported (47% and 43% respectively). Misoprostol users were significantly more likely to experience shivering, high temperature, nausea, and vomiting after delivery; adjustment for gynecological history and delivery characteristics revealed no significant differences in experience of symptoms. Misoprostol was highly acceptable to all women surveyed. Misoprostol at the community level is a safe intervention.
本文通过比较坦桑尼亚基戈马社区使用米索前列醇和未使用米索前列醇的分娩情况，评估了在家庭分娩中基于社区长期使用米索前列醇治疗产后出血（PPH）的安全性和可接受性。我们对2004年8月至2007年5月期间分娩的妇女进行了标准化调查。940名妇女完成了问卷调查，对应950次分娩。结果显示，大多数传统助产士在正确时间使用了米索前列醇（76%）。最常报告的是接受三片或五片米索前列醇（分别为47%和43%）。使用米索前列醇的产妇在分娩后出现寒战、高热、恶心和呕吐的可能性显著更高；对妇科病史和分娩特征进行调整后发现，症状体验无显著差异。米索前列醇为所有接受调查的妇女所高度接受。在社区层面使用米索前列醇是一种安全的干预措施。
