孕激素受体的较低 Allred 评分与乳腺癌 21 基因检测的较高复发评分强烈相关。
A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.
机构信息
Department of Pathology, University of Rochester of Rochester Medical Center, New York, USA.
出版信息
Cancer Invest. 2010 Nov;28(9):978-82. doi: 10.3109/07357907.2010.496754.
Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) -2.408 (PR) -1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R² of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.
在 77 例浸润性乳腺癌中，我们发现孕激素受体（PR）表达与复发评分（RS）呈负相关（p<0.0001）。RS 还与管腔形成、有丝分裂和腔 B 型显著相关。RS 的方程为 RS=17.489+2.071（管腔形成）+2.926（有丝分裂）-2.408（PR）-1.061（HER2）+7.051（腔 A）+29.172（腔 B），其预测 RS 的 R²为 0.65。总之，PR 阴性、腔 B 型、管腔形成和有丝分裂与较高的 RS 密切相关。
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