The Second Xiangya Hospital of Central South University, Institute of Endocrinology & Metabolism, Changsha, Hunan 410011, PR China.
Expert Opin Ther Targets. 2010 Oct;14(10):1109-20. doi: 10.1517/14728222.2010.512916.
Bone tissue arises from mesenchymal stromal cells (MSCs) differentiated into the osteoblast lineage by genetic and epigenetic mechanisms. Emerging evidence indicates that the class of small non-coding single-stranded RNAs known as "microRNAs (miRNAs)" also plays a critical role in this process.
In this short review, we summarize the biology and functional mechanisms of miRNAs. Importantly, we discuss miRNA expression, miRNA function, miRNA target prediction, miRNA overexpression and inhibition methods applied in osteoblastogenesis.
We discuss the potential therapeutic opportunities and challenges for improving the treatment of bone-related diseases by using miRNAs as a therapeutic target.
Although various microRNAs regulate cell proliferation and differentiation, only a few miRNAs has been reported so far to play a key role in the regulation of osteoblast differentiation and bone formation.
骨组织来源于间充质基质细胞（MSCs），通过遗传和表观遗传机制分化为成骨细胞谱系。新出现的证据表明，一类被称为“microRNAs（miRNAs）”的小非编码单链 RNA 也在这个过程中发挥着关键作用。
在这篇简短的综述中，我们总结了 miRNAs 的生物学和功能机制。重要的是，我们讨论了 miRNA 的表达、miRNA 的功能、miRNA 靶预测、在成骨细胞发生中应用的 miRNA 过表达和抑制方法。
我们讨论了通过将 miRNAs 作为治疗靶点来改善与骨骼相关疾病治疗的潜在治疗机会和挑战。
虽然各种 microRNAs 调节细胞增殖和分化，但迄今为止，只有少数 microRNAs 被报道在调节成骨细胞分化和骨形成方面发挥关键作用。
