Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark.
Contact Dermatitis. 2010 Sep;63(3):146-50. doi: 10.1111/j.1600-0536.2010.01743.x.
The Compositae plant feverfew (Tanacetum parthenium) has long been recognized as an important sensitizer in European Compositae-allergic patients, mainly because of its content of the sesquiterpene lactone parthenolide. Recently, a parthenolide-depleted feverfew extract with claimed anti-inflammatory properties has been developed for use in cosmetics.
The aim of the study was to test, on the basis of patch test reactions, whether persons with contact allergy to feverfew could tolerate creams containing this feverfew extract.
PATIENTS/MATERIALS/METHODS: Seven patients with feverfew contact allergy were patch tested with two creams containing the feverfew extract. Subsequently, the creams were analysed by liquid chromatography with tandem mass spectrometry to detect parthenolide.
Four of the patients tested positive to one of the creams; reactivity was associated with simultaneous positive reactions to parthenolide. This cream was analysed about 2 years later, and no parthenolide was detected, probably because of degradation of the compound.
Topical products containing parthenolide-depleted feverfew extracts may elicit positive patch test reactions in feverfew-sensitive patients. The reactivity may be enhanced by simultaneous testing with parthenolide, but the reactivity is lost over time, probably because of degradation of parthenolide.
菊科植物小白菊（Tanacetum parthenium）长期以来一直被认为是欧洲菊科过敏患者的重要致敏原，主要是因为其含有倍半萜内酯母菊内酯。最近，一种据称具有抗炎特性的脱母菊内酯小白菊提取物已被开发用于化妆品。
本研究旨在根据斑贴试验反应，测试对小白菊过敏的患者是否能耐受含有这种小白菊提取物的乳膏。
患者/材料/方法：7 名对小白菊过敏的患者进行了斑贴试验，使用了两种含有小白菊提取物的乳膏。随后，通过液相色谱-串联质谱法对乳膏进行了分析，以检测母菊内酯。
其中 4 名患者对其中一种乳膏呈阳性反应；反应性与同时对母菊内酯的阳性反应有关。大约 2 年后对这种乳膏进行了分析，没有检测到母菊内酯，可能是因为化合物降解了。
含有脱母菊内酯小白菊提取物的局部产品可能会在对小白菊敏感的患者中引起阳性斑贴试验反应。同时进行母菊内酯测试可能会增强反应性，但随着时间的推移，反应性会丧失，可能是因为母菊内酯降解了。
