Paulsen Evy, Chistensen Lars P, Andersen Klaus E
National Allergy Research Centre, Gentofte, Denmark.
Contact Dermatitis. 2008 Jan;58(1):15-23. doi: 10.1111/j.1600-0536.2007.01250.x.
Compositae-sensitive patients are routinely warned against topical use of Compositae-containing cosmetics and herbal remedies. However, the risk of elicitation of dermatitis in presensitized persons is unknown.
The main aim of this study was to assess the significance of direct plant allergen contact via Compositae-derived cosmetics and herbal remedies in Compositae-allergic patients with special reference to arnica (Arnica montana) and German chamomile (Chamomilla recutita).
8 of 12 chamomile-sensitive patients tested positive to chamomile-containing preparations, including tea, creams, ointments, and oil. 5 of 6 arnica-sensitive persons tested positive to arnica-based products.
When the group was patch tested with cosmetic and/or herbal product ingredients, plant allergens elicited positive reactions most frequently, but fragrances, emulsifiers, and preservatives tested positive as well. Plant allergens were mainly derived from Compositae, but avocado oil, and Hamamelis virginiana tincture were unexpectedly detected as sensitizers too. Chemical analyses indicated that the Compositae allergens were both sesquiterpene lactones and other naturally occurring compounds.
In conclusion, Compositae-allergic persons should be warned against topical use of Compositae-containing products, not only because of the plant allergens, but also because of allergenic cream constituents that may cause reactions in the group of patients who have multiple contact allergies beside the Compositae allergy.
菊科植物敏感患者通常被常规警告不要局部使用含菊科植物的化妆品和草药。然而，预致敏个体引发皮炎的风险尚不清楚。
本研究的主要目的是评估菊科植物过敏患者通过菊科植物衍生的化妆品和草药直接接触植物过敏原的重要性，特别提及山金车（Arnica montana）和德国洋甘菊（Chamomilla recutita）。
12名洋甘菊敏感患者中有8人对含洋甘菊的制剂呈阳性反应，包括茶、乳膏、软膏和油。6名山金车敏感者中有5人对山金车产品呈阳性反应。
当该组用化妆品和/或草药产品成分进行斑贴试验时，植物过敏原最常引发阳性反应，但香料、乳化剂和防腐剂也呈阳性反应。植物过敏原主要来源于菊科植物，但鳄梨油和北美金缕梅酊剂也意外地被检测为致敏原。化学分析表明，菊科植物过敏原既有倍半萜内酯，也有其他天然存在的化合物。
总之，应警告菊科植物过敏者不要局部使用含菊科植物的产品，不仅是因为植物过敏原，还因为过敏乳膏成分可能会在除菊科植物过敏外还患有多种接触性过敏的患者群体中引起反应。
