Effects of auranofin on endothelium dependent contractions in isolated rat aorta.
作者信息
Fontaine J, Fang Z Y, Berkenboom G, Famaey J P
机构信息
Laboratory of Pharmacology, Erasmus Hospital, Belgium.
出版信息
Agents Actions Suppl. 1991;32:83-7. doi: 10.1007/978-3-0348-7405-2_11.
PMID:2069099
Abstract
Auranofin (10(-6) and 10(-5)M) reduces the acetylcholine induced relaxation in the isolated rat aorta. Contractions induced by phenylephrine and 5-hydroxytryptamine are enhanced by auranofin 10(-6)M only when endothelium is present. At higher concentration (10(-5)M), it antagonizes the agonist-induced contractions either in the presence or absence of endothelium.
摘要
Zotero 插件