Puskar M A, Szopinski F G, Hecker L H
Corporate Industrial Hygiene Laboratory, Abbott Laboratories, North Chicago, IL 60064.
Am Ind Hyg Assoc J. 1991 Apr;52(4):145-50. doi: 10.1080/15298669191364497.
An exposure and analysis protocol is described for the field validation of passive dosimeters for ethylene oxide (EtO) excursion limit monitoring. The protocol calls for the use of a field exposure chamber with concurrent sampling using Tedlar air-sampling bags. The bags are analyzed immediately after sampling by gas chromatography with flame ionization detection (GC-FID). The chamber design allows all monitors to be exposed for the exact same time in the field. The sampling and analysis procedure not only determines the actual concentration of EtO present during the monitor's exposure but estimates if concentrations of EtO vary from point to point in the monitor array during the exposure. In chamber operation, the accuracy of the standard generator used to calibrate the GC-FID was independently verified in the field by the standard additions method. The sampling bias of the sampling train was determined to be -3.5% in the 2.4 ppm to 14.3 ppm concentration range. To estimate the stability of collected EtO samples in Tedlar bags, the rate of EtO loss in the bags was determined to be 0.011 ppm/hr at 2.57 ppm and 0.066 ppm/hr at 8.07 ppm. Sampling bias of the passive methods by additional EtO exposure of the monitors in the closed chamber after sampling and during purging was determined to be +1.5%. The Tedlar bag sampling method with subsequent GC-FID determination demonstrated a coefficient of variation of 1.8% at 2.43 ppm.
描述了一种用于环氧乙烷（EtO）暴露极限监测的被动剂量计现场验证的暴露与分析方案。该方案要求使用现场暴露室，并使用泰德拉空气采样袋进行同步采样。采样后立即通过带有火焰离子化检测的气相色谱法（GC-FID）对袋子进行分析。该室的设计使得所有监测器在现场能够暴露完全相同的时间。采样和分析程序不仅能确定监测器暴露期间实际存在的EtO浓度，还能估计暴露期间监测器阵列中各点的EtO浓度是否存在差异。在室操作中，通过标准加入法在现场独立验证了用于校准GC-FID的标准发生器的准确性。在2.4 ppm至14.3 ppm浓度范围内，采样系统的采样偏差确定为-3.5%。为了估计泰德拉袋中收集的EtO样品的稳定性，确定袋子中EtO的损失率在2.57 ppm时为0.011 ppm/小时，在8.07 ppm时为0.066 ppm/小时。在采样后和吹扫期间，通过在封闭室内对监测器进行额外的EtO暴露来确定被动方法的采样偏差为+1.5%。随后进行GC-FID测定的泰德拉袋采样方法在2.43 ppm时的变异系数为1.8%。
