Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Am J Obstet Gynecol. 2010 Oct;203(4):381.e1-4. doi: 10.1016/j.ajog.2010.06.013. Epub 2010 Aug 9.
Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies.
P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques.
P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks.
Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation.
与单胎妊娠相比，双胎妊娠的女性可能有更高的孤立性蛋白尿发生率。我们比较了无并发症的双胎和单胎妊娠患者在整个妊娠期间纵向的蛋白/肌酐（P：C）比值。
在 102 例（51 例双胎，51 例单胎）无先兆子痫发生的健康孕妇中，在 3 个时间点比较了 P：C 比值，使用线性和逻辑回归技术。
所有患者的 P：C 比值在整个妊娠期间均显著增加。在双胞胎中，这种增加明显高于单胎。34 周至 38 周时，双胞胎 P：C 比值>0.19 的几率是单胎的 3.5 倍。
与单胎妊娠相比，无并发症的双胎妊娠女性的 P：C 比值显示出更高的蛋白排泄量。在孕早期，蛋白排泄量相似，但在妊娠后期明显不同。我们建议，双胎妊娠的蛋白尿正常值可能与单胎妊娠不同，需要进一步评估。
