Wark H, Earl J, Chau D, Overton J
Department of Anaesthesia, Royal Alexandra Hospital for Children, Sydney, N.S.W., Australia.
Anaesth Intensive Care. 1991 May;19(2):213-6. doi: 10.1177/0310057X9101900210.
In humans the biliary excretion of trifluoroacetic acid, the major halothane metabolite, has not been studied. We investigated the biliary excretion of trifluoroacetic acid in two infants aged five months and two months following halothane anaesthesia for the operation of choledocholithotomy. Bile, urine and faeces were collected continuously for five days after operation and trifluoroacetic acid excretion measured. Estimates of halothane uptake, daily bile flow and the proportion of daily bile flow collected via the T-tube drainage catheter were subject to percentage errors possibly as large as 50%. Of the total trifluoroacetic acid produced from halothane metabolism, it was estimated that 17% in the five-month-old infant and 20% in the two-month infant was excreted in bile. In the five-month-old infant where approximately 80% of the bile produced entered the duodenum in the normal way, no faecal trifluoroacetic acid was detected suggesting an enterohepatic circulation for this metabolite.
在人类中，尚未对主要的氟烷代谢产物三氟乙酸的胆汁排泄情况进行研究。我们调查了两名分别为五个月和两个月大的婴儿在接受氟烷麻醉进行胆总管切开取石术后三氟乙酸的胆汁排泄情况。术后连续五天收集胆汁、尿液和粪便，并测定三氟乙酸的排泄量。氟烷摄取量、每日胆汁流量以及通过T形管引流导管收集的每日胆汁流量比例的估计值可能存在高达50%的百分比误差。据估计，在五个月大的婴儿中，氟烷代谢产生的三氟乙酸总量中有17%通过胆汁排泄，在两个月大的婴儿中这一比例为20%。在五个月大的婴儿中，大约80%产生的胆汁以正常方式进入十二指肠，未检测到粪便中有三氟乙酸，这表明该代谢产物存在肠肝循环。
