Department of Dermatology, University Hospital of Zurich, Switzerland.
Lupus. 2010 Aug;19(9):1078-86. doi: 10.1177/0961203310373938.
Lupus erythematosus (LE) is a systemic autoimmune disorder associated with polyclonal B-cell activation resulting in diverse patterns of autoantibody production and a heterogeneous clinical expression constituting a spectrum extending from limited cutaneous disease to life-threatening systemic manifestations. For daily clinical practice, the characteristics of cutaneous lupus erythematosus (CLE) have been well defined in terms of morphology, and clinical and laboratory criteria are available for the classification as systemic lupus erythematosus (SLE). The many different types of skin lesions encountered in patients with LE have been classified into those that are histologically specific for LE and those that are not. While LE non-specific skin lesions on their own do not enable a diagnosis of LE, they can be important reflections of underlying SLE disease activity. This also applies to the involvement of the scalp and nails. Finally, it must be kept in mind that LE patients may also develop drug-related, or other unrelated common disorders of the hair and nails that do not reflect LE disease activity.
红斑狼疮（LE）是一种与多克隆 B 细胞激活相关的系统性自身免疫性疾病，导致产生多种自身抗体，并表现出异质性的临床特征，构成了从局限性皮肤疾病到危及生命的系统性表现的谱。对于日常临床实践，已根据形态学明确界定了皮肤红斑狼疮（CLE）的特征，并且可获得用于分类为系统性红斑狼疮（SLE）的临床和实验室标准。在患有 LE 的患者中遇到的许多不同类型的皮肤病变可分为那些具有 LE 组织学特异性的病变和那些不具有 LE 组织学特异性的病变。虽然 LE 的非特异性皮肤病变本身不能诊断为 LE，但它们可以反映潜在的 SLE 疾病活动。这也适用于头皮和指甲的受累。最后，必须记住，LE 患者也可能会出现与药物相关的或其他与 LE 疾病活动无关的常见毛发和指甲疾病。
