Lestradet H, Deschamps I
Ann Pediatr (Paris). 1991 Apr;38(4):255-9.
Two per cent of "diabetic" children actually exhibit a specific condition which is not a disease in the conventional acceptance of the term. Characteristics of this biologic anomaly, whose pathophysiology is as yet incompletely understood, include the absence of clinical manifestations, with the diagnosis being established upon routine tests (e.g., as part of a school health check-up or during screening tests in family members of diabetics); blood glucose levels or glucose tolerance test results consistently above the 97th percentile of reference values, with some degree of variation over time; normal serum insulin levels; glycosylated hemoglobin levels usually near the upper limit of normal; dominant autosomal inheritance; lack of association with either HLA markers or insulin-dependent diabetes mellitus; lack of microvascular degenerative disease, at least in this study group, even after more than 30 years follow-up; lack of progression towards insulin-dependent diabetes mellitus.
2%的“糖尿病”儿童实际上表现出一种特殊情况，从该术语的传统定义来看，这并非一种疾病。这种生物学异常的特征包括没有临床表现，其诊断是通过常规检查确立的（例如，作为学校健康检查的一部分，或在糖尿病患者家庭成员的筛查测试期间）；血糖水平或葡萄糖耐量测试结果持续高于参考值的第97百分位数，且随时间有一定程度的变化；血清胰岛素水平正常；糖化血红蛋白水平通常接近正常上限；常染色体显性遗传；与HLA标记或胰岛素依赖型糖尿病均无关联；至少在该研究组中，即使经过30多年的随访，也没有微血管退行性疾病；不会发展为胰岛素依赖型糖尿病。
