Rosario Pedro Weslley
Santa Casa de Belo Horizonte, Departamento de Neuroendocrinologia, Santa Casa de Belo Horizonte, MG, Brazil.
Arq Bras Endocrinol Metabol. 2010;54(5):477-81. doi: 10.1590/s0004-27302010000500008.
To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population.
Healthy volunteers were divided into 10 groups according to age (5-year intervals), with 100 subjects (50 men and 50 women) per group. One-hundred participants were selected for repetition of the test after 12 weeks.
No difference in IGF-1 values was observed between men and women, but a progressive reduction of serum IGF-1 with age was seen. The reference values provided by the manufacturer of the assay, although discretely higher, were very close to the values found in this study. A second measurement of IGF-1 after 12 weeks revealed a variation < 20% in 99% of subjects.
This study established the reference range for IGF-1 determined with the Immulite 2000 assay for a large number of healthy Brazilian adults stratified according to age, and suggests that variations > 20% in IGF-1 levels within an interval of 12 weeks cannot be attributed to interassay variability.
确定巴西成年人（21 - 70岁）群体中血清IGF - 1（免疫发光法2000）的正常值。
健康志愿者按年龄（每5年为一个间隔）分为10组，每组100名受试者（50名男性和50名女性）。100名参与者在12周后被选出来重复测试。
未观察到男性和女性之间IGF - 1值存在差异，但血清IGF - 1值随年龄增长呈逐渐下降趋势。该检测方法制造商提供的参考值虽略高，但与本研究中发现的值非常接近。12周后对IGF - 1进行的第二次测量显示，99%的受试者变化<20%。
本研究确定了采用免疫发光法2000检测的IGF - 1在大量按年龄分层的健康巴西成年人中的参考范围，并表明在12周的间隔内IGF - 1水平变化>20%不能归因于检测间的变异性。
