Zhu Huijuan, Xu Yuan, Gong Fengying, Shan Guangliang, Yang Hongbo, Xu Ke, Zhang Dianxi, Cheng Xinqi, Zhang Zhihao, Chen Shi, Wang Linjie, Pan Hui
Department of Endocrinology, Key Laboratory of Endocrinology of National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
PLoS One. 2017 Oct 4;12(10):e0185561. doi: 10.1371/journal.pone.0185561. eCollection 2017.
To determine serum insulin-like growth factor 1 (IGF-I) levels in healthy Chinese adults, establish reference ranges for serum IGF-I levels and observe the effects of age, sex, body mass index (BMI) and geographical region on serum IGF-I levels.
In total, 2791 healthy adults (1339 males and 1452 females) from the north (Beijing) and south (Guizhou Province) of China were recruited following a questionnaire survey, physical examination and laboratory examination. Both sexes were divided into 13 groups according to age (18, 19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69 and ≥70 years). The serum IGF-I levels were measured by performing a chemiluminescent assay (Immulite 2000®), and the LMS (Lambda-Mu-Sigma) method was applied to construct smooth centile curves of age-specific IGF-I levels.
Serum IGF-I levels in the adults gradually decreased with increasing age from 18 to 70 years in both the male and female participants. Although the decrease in the level of IGF-1 was more pronounced in females than in males, no significant difference was observed between the sexes, except in the 60- to 64-year-old age group (P = 0.0329). The multiple linear regression model showed that there was an inverse relationship between the serum IGF-I level and BMI (P<0.001), and the serum IGF-I level in the Guizhou population was higher than that in the Beijing population (P<0.05).
The normal reference ranges for age- and sex-specific serum IGF-I levels were established for the first time in a large sample of Chinese adults. The serum IGF-I levels were significantly influenced by age, BMI and geographical region.
测定健康中国成年人血清胰岛素样生长因子1（IGF-I）水平，建立血清IGF-I水平的参考范围，并观察年龄、性别、体重指数（BMI）和地理区域对血清IGF-I水平的影响。
通过问卷调查、体格检查和实验室检查，共招募了来自中国北方（北京）和南方（贵州省）的2791名健康成年人（男性1339名，女性1452名）。根据年龄（18、19、20 - 24、25 - 29、30 - 34、35 - 39、40 - 44、45 - 49、50 - 54、55 - 59、60 - 64、65 - 69和≥70岁）将男女分为13组。采用化学发光法（Immulite 2000®）测定血清IGF-I水平，并应用LMS（Lambda-Mu-Sigma）法构建特定年龄IGF-I水平的平滑百分位数曲线。
在18至70岁的成年男性和女性参与者中，血清IGF-I水平均随年龄增长而逐渐下降。尽管女性IGF-1水平的下降比男性更明显，但除60至64岁年龄组外，两性之间未观察到显著差异（P = 0.0329）。多元线性回归模型显示，血清IGF-I水平与BMI呈负相关（P<0.001），贵州人群的血清IGF-I水平高于北京人群（P<0.05）。
首次在大量中国成年人样本中建立了按年龄和性别划分的血清IGF-I水平正常参考范围。血清IGF-I水平受年龄、BMI和地理区域的显著影响。
