College of Kinesiology, University of Saskatchewan, Saskatoon, Canada.
Am J Perinatol. 2011 Feb;28(2):157-63. doi: 10.1055/s-0030-1263299. Epub 2010 Aug 6.
The purpose of this study was to determine the influence of preterm low birth weight on bone mineral content in adolescence. In 2007 to 2008, data on adolescents were obtained for study, including 16 females and 25 males who were born preterm (≤37 weeks' gestation) between October 1, 1989, and December 31, 1995, with a birth weight of less than 1850 g. Preterm low-birth-weight individuals were age- and sex-matched to full-term (>37 weeks) normal-birth-weight (>2500 g) controls. Total body, hip, and spine bone mineral content (BMC) was assessed using dual energy X-ray absorptiometry. Male preterm individuals had less BMC at the proximal femur in adolescence compared with controls ( p < 0.05). However, once adjusted for age, maturity, height, weight, physical activity, and diet, there were no differences between groups ( p < 0.05) in any bone parameters. These findings suggest that preterm birth and low birth weight did not influence bone accrual in these individuals at adolescence.
本研究旨在探讨早产儿低出生体重对青少年时期骨矿物质含量的影响。2007 年至 2008 年，研究获得了青少年的数据，包括 1989 年 10 月 1 日至 1995 年 12 月 31 日期间出生的 16 名女性和 25 名男性早产儿（妊娠 37 周以下），出生体重小于 1850 克。将早产儿低出生体重个体与足月（>37 周）正常出生体重（>2500 克）对照组进行年龄和性别匹配。采用双能 X 射线吸收法评估全身、髋部和脊柱的骨矿物质含量（BMC）。与对照组相比，青春期男性早产儿的股骨近端 BMC 较少（p<0.05）。然而，在调整年龄、成熟度、身高、体重、体力活动和饮食后，两组之间在任何骨参数上均无差异（p<0.05）。这些发现表明，早产和低出生体重并未影响这些个体在青少年时期的骨积累。
