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抗病毒伊塔罗卡拉胶鼻喷剂的疗效和安全性：一项在有普通感冒早期症状的志愿者中进行的随机、双盲、安慰剂对照探索性研究。

Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.

机构信息

Marinomed Biotechnologie GmbH, Veterinaerplatz 1, Vienna, Austria.

出版信息

Respir Res. 2010 Aug 10;11(1):108. doi: 10.1186/1465-9921-11-108.

DOI:10.1186/1465-9921-11-108
PMID:20696083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2923116/
Abstract

BACKGROUND

The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms.

METHODS

In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo.

RESULTS

Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold (p = 0.046) and the viral load in nasal lavages (p = 0.009) in patients with early symptoms of common cold. Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group.

CONCLUSIONS

Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. Larger trials are indicated to confirm the results.

摘要

背景

普通感冒是人类最常见的传染性病毒性疾病，但目前仍缺乏安全有效的抗病毒治疗方法。iota-卡拉胶在体外对呼吸道病毒具有广泛的活性，且安全性良好。本研究旨在探究 iota-卡拉胶鼻喷剂治疗普通感冒症状的疗效和安全性。

方法

在一项随机、双盲、安慰剂对照的探索性试验中，35 名患有普通感冒早期症状的受试者接受了 iota-卡拉胶（0.12%）生理盐水溶液，每日 3 次，连续 4 天，与安慰剂进行比较。

结果

iota-卡拉胶鼻喷剂的给药可减轻普通感冒症状（p=0.046），并降低普通感冒早期患者鼻冲洗液中的病毒载量（p=0.009）。在 iota-卡拉胶组中，促炎介质 FGF-2、Fractalkine、GRO、G-CSF、IL-8、IL-1α、IP-10、IL-10 和 IFN-α2 的水平降低。

结论

iota-卡拉胶鼻喷剂似乎是一种有前途的治疗方法，可安全有效地治疗普通感冒的早期症状。需要更大规模的试验来证实这些结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/93a0092bcda6/1465-9921-11-108-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/5c4ef3d9b5a2/1465-9921-11-108-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/c79c878ea829/1465-9921-11-108-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/773b6580adcd/1465-9921-11-108-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/93a0092bcda6/1465-9921-11-108-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/5c4ef3d9b5a2/1465-9921-11-108-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/c79c878ea829/1465-9921-11-108-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/773b6580adcd/1465-9921-11-108-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b1/2923116/93a0092bcda6/1465-9921-11-108-4.jpg

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