Razali Rabiatul Adawiyah, Muhammad Firdaus Fairuz Izan, Fauzi Mh Busra, Mobarak Nadhratun Naiim, Aminuddin Saim, Lokanathan Yogeswaran
Medical Innovation Research Centre (MIRC), Shiga University of Medical Science, 520-2192 Otsu, Shiga, Japan.
Department of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Polymers (Basel). 2024 Nov 30;16(23):3387. doi: 10.3390/polym16233387.
Nasal packing is a critical procedure in postoperative care and trauma management aimed at controlling bleeding, providing structural support, and promoting tissue healing. However, conventional nasal packs often lead to discomfort, infection risks, and secondary tissue damage. To address these challenges, this study explores the potential use of biodegradable and biocompatible gelatin-carrageenan composite scaffolds as an alternative nasal packing material. Five compositions of gelatin-carrageenan scaffolds (ratios 10:0, 7:3, 5:5, 3:7, and 0:10) were fabricated and evaluated for physicochemical properties, hemocompatibility, and cytocompatibility. Results suggest that balanced ratios, such as 7:3 and 5:5, may provide a combination of structural integrity, improved biocompatibility, and controlled degradation, making them a potential candidate for nasal packing applications. The scaffolds exhibited low cytotoxicity and reasonable blood compatibility, which could reduce the risks associated with conventional materials. While these findings are promising, further in vivo studies are necessary to validate the efficacy and safety of these scaffolds in clinical settings. If proven effective, gelatin-carrageenan scaffolds may help address some of the limitations of conventional nasal packing materials and improve postoperative care outcomes.
鼻腔填塞是术后护理和创伤处理中的一项关键操作，旨在控制出血、提供结构支撑并促进组织愈合。然而，传统的鼻腔填塞物常常会导致不适、感染风险以及继发性组织损伤。为应对这些挑战，本研究探索了可生物降解且具有生物相容性的明胶 - 卡拉胶复合支架作为替代鼻腔填塞材料的潜在用途。制备了五种明胶 - 卡拉胶支架组合物（比例分别为10:0、7:3、5:5、3:7和0:10），并对其理化性质、血液相容性和细胞相容性进行了评估。结果表明，诸如7:3和5:5这样的平衡比例可能会提供结构完整性、改善的生物相容性和可控降解性的组合，使其成为鼻腔填塞应用的潜在候选材料。这些支架表现出低细胞毒性和合理的血液相容性，这可以降低与传统材料相关的风险。虽然这些发现很有前景，但还需要进一步的体内研究来验证这些支架在临床环境中的有效性和安全性。如果被证明有效，明胶 - 卡拉胶支架可能有助于解决传统鼻腔填塞材料的一些局限性，并改善术后护理效果。
