急性髓系白血病缓解后治疗的种族和强度。
Race and intensity of post-remission therapy in acute myeloid leukemia.
机构信息
Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
出版信息
Leuk Res. 2011 Mar;35(3):346-50. doi: 10.1016/j.leukres.2010.07.020. Epub 2010 Aug 8.
BACKGROUND
In many cancers, including AML, blacks have poorer overall survival. We investigated whether differences in post-remission therapy (PRT) were a contributing factor.
METHODS
We compared PRT cycle number and intensity and time to PRT in blacks and whites, among 460 patients with newly diagnosed AML.
RESULTS
Blacks and whites had PRT of equal cycle intensity and number, but black patients experienced a significant delay in starting PRT (2.73 months in blacks vs. 1 month in whites, p=0.047). Overall survival was equivalent in blacks and whites.
CONCLUSION
PRT is delayed in blacks but does not explain differences in survival.
背景
在许多癌症中，包括急性髓系白血病（AML），黑人的总体生存率较差。我们研究了缓解后治疗（PRT）的差异是否是一个促成因素。
方法
我们比较了 460 名新诊断为 AML 的患者中黑人与白人的 PRT 周期数和强度以及开始 PRT 的时间。
结果
黑人与白人的 PRT 周期强度和数量相同，但黑人患者开始 PRT 的时间明显延迟（黑人患者为 2.73 个月，白人患者为 1 个月，p=0.047）。黑人与白人的总体生存率相当。
结论
黑人的 PRT 延迟，但不能解释生存差异。
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