一例罕见的血清阴性神经型布鲁氏菌病病例。
A rare case of seronegative neurobrucellosis.
作者信息
Tekin-Koruk Suda, Duygu Fazilet, Gursoy Bensu, Karaagac Leman, Bayraktar Mehmet
机构信息
Harran University, Infectious Diseases and Clinical Microbiology Sanliurfa, Turkey.
出版信息
Ann Saudi Med. 2010 Sep-Oct;30(5):412-4. doi: 10.4103/0256-4947.67084.
Abstract
Neurobrucellosis is one of the complications of brucellosis. We report a rare case of a 17-year-old girl with seronegative neurobrucellosis and depression and diplopia. Results of agglutination tests for Brucella both in serum and CSF were negative. Diagnosis was made only by positive culture of Brucella mellitensis with inoculation of the patient's cerebrospinal fluid in a BACTEC 9050 System. The patient was successfully treated using ceftriaxone, doxycycline and rifampicin therapy for six months.
摘要
神经型布鲁氏菌病是布鲁氏菌病的并发症之一。我们报告了一例罕见的17岁女孩病例，她患有血清阴性神经型布鲁氏菌病，伴有抑郁和复视。血清和脑脊液中布鲁氏菌凝集试验结果均为阴性。仅通过在BACTEC 9050系统中接种患者脑脊液，马尔他布鲁氏菌培养呈阳性才得以确诊。患者通过头孢曲松、强力霉素和利福平联合治疗六个月后成功治愈。
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本文引用的文献
1
Management of neurobrucellosis: an assessment of 11 cases.神经型布鲁氏菌病的管理：11例病例评估
Intern Med. 2008;47(11):995-1001. doi: 10.2169/internalmedicine.47.0866. Epub 2008 Jun 2.
2
Brucellosis.布鲁氏菌病
N Engl J Med. 2005 Jun 2;352(22):2325-36. doi: 10.1056/NEJMra050570.
3
Isolated intracranial hypertension: a rare presentation of neurobrucellosis.孤立性颅内高压：神经型布鲁氏菌病的一种罕见表现。
Microbes Infect. 2004 Jul;6(9):861-3. doi: 10.1016/j.micinf.2004.04.012.
4
Unusual clinical presentations of brucellosis.布鲁氏菌病的不典型临床表现。
Scand J Infect Dis. 2004;36(9):694-7. doi: 10.1080/00365540410017554.
5
Neurobrucellosis in an endemic area of brucellosis.布鲁氏菌病流行地区的神经型布鲁氏菌病
Scand J Infect Dis. 2003;35(2):94-7. doi: 10.1080/0036554021000027000.
6
Optimum detection times for bacteria and yeast species with the BACTEC 9120 aerobic blood culture system: evaluation for a 5-year period in a Turkish university hospital.使用BACTEC 9120需氧血培养系统检测细菌和酵母菌的最佳时间：土耳其一家大学医院5年的评估
J Clin Microbiol. 2003 Feb;41(2):819-21. doi: 10.1128/JCM.41.2.819-821.2003.
7
Meningoencephalitis in brucellosis.
Neurol India. 2000 Jun;48(2):170-3.
8
Brucella bacteraemia: clinical and laboratory observations in 160 patients.布鲁氏菌血症：160例患者的临床及实验室观察
J Infect. 2000 Jan;40(1):59-63. doi: 10.1053/jinf.1999.0586.
9
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10
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Clin Infect Dis. 1995 Aug;21(2):283-9; quiz 290. doi: 10.1093/clinids/21.2.283.
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