Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33125, USA.
Curr Neurol Neurosci Rep. 2010 Nov;10(6):467-75. doi: 10.1007/s11910-010-0138-y.
Although major advancements have been made in the treatment of HIV infection, graft-versus-host reactions, and autoimmune diseases, an unexpected consequence of treatment has been the emergence of a devastating inflammatory syndrome, termed the immune reconstitution inflammatory syndrome (IRIS). The pathophysiology of the syndrome is poorly understood, and the syndrome poses unique challenges for diagnosis and treatment. We have reviewed the neurologic manifestations of IRIS in the context of HIV infection as well as in the setting of treatment of autoimmune diseases such as multiple sclerosis, in which compartmental immune suppression may occur without an obvious underlying immune suppression. The purpose of this review is to identify common themes that may assist in the diagnosis and management of these IRIS syndromes.
尽管在治疗 HIV 感染、移植物抗宿主反应和自身免疫性疾病方面取得了重大进展，但治疗的一个意外后果是出现了一种破坏性的炎症综合征，称为免疫重建炎症综合征（IRIS）。该综合征的病理生理学尚未完全了解，并且该综合征在诊断和治疗方面带来了独特的挑战。我们回顾了 HIV 感染以及多发性硬化症等自身免疫性疾病治疗中 IRIS 的神经表现，在这些情况下，免疫抑制可能发生而没有明显的潜在免疫抑制。本综述的目的是确定可能有助于诊断和管理这些 IRIS 综合征的常见主题。
