Dilege Ece, Mihmanli Mehmet, Demir Uygar, Ozer Kadir, Bostanci Ozgür, Kaya Cemal, Aksakal Oznur, Sakiz Damlanur
Sisli Etfal Training and Research Hospital, Department of General Surgery, Etfal sok, Sişli, Istanbul, Turkey.
Hepatogastroenterology. 2010 May-Jun;57(99-100):674-7.
BACKGROUND/AIMS: Preoperative tumor marker assays have been used to predict the prognosis of gastric cancer, but the exact role they may play is still unclear. The aim of this study was to evaluate the clinical significance of preoperative serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels in resectable gastric cancer patients.
Seventy-five resectable, nonmetastatic gastric cancer patients were analysed in regard to their clinicopathological characteristics and their relation with tumor markers and influence on survival have been evaluated.
Twenty-eight patients were female and 47 were male. The mean age was 61 years (range 21-85 years). Fifty-two patients had total gastrectomy, and 23 had a subtotal gastrectomy with D2 lymph node dissection. The median follow up period was 24 months (6-74 months). Elevated serum CA 19-9 levels correlated well with lymph node metastasis (p = 0.008), stage (p = 0.012), vascular invasion (p = 0.03) and tumor size (p = 0.001). The survival of the patients were not correlated with the tumor markers (p > 0.05).
Elevated CA 19-9 levels are significantly correlated with lymph node metastasis, which may improve the selection of patients with advanced disease. CEA and CA 19-9 levels do not provide any predictive information about survival of operable, nonmetastatic gastric cancer patients.
背景/目的：术前肿瘤标志物检测已被用于预测胃癌的预后，但其确切作用仍不明确。本研究旨在评估术前血清癌胚抗原（CEA）和糖类抗原（CA）19-9水平在可切除胃癌患者中的临床意义。
分析75例可切除、无转移的胃癌患者的临床病理特征，并评估其与肿瘤标志物的关系及其对生存的影响。
28例为女性，47例为男性。平均年龄61岁（范围21-85岁）。52例行全胃切除术，23例行D2淋巴结清扫的胃次全切除术。中位随访期为24个月（6-74个月）。血清CA 19-9水平升高与淋巴结转移（p = 0.008）、分期（p = 0.012）、血管侵犯（p = 0.03）和肿瘤大小（p = 0.001）密切相关。患者的生存与肿瘤标志物无关（p > 0.05）。
CA 19-9水平升高与淋巴结转移显著相关，这可能有助于改善晚期疾病患者的选择。CEA和CA 19-9水平不能提供关于可手术、无转移胃癌患者生存的任何预测信息。
