Lyras Dimitrios N, Kazakos Konstantinos, Verettas Dionysios, Chronopoulos Efstathios, Folaranmi Semiu, Agrogiannis George
Department of Orthopaedic and Trauma Surgery, Democritus University of Thrace, Alexandroupolis, Greece.
Acta Orthop Belg. 2010 Jun;76(3):380-6.
The aim of this study was to test the hypothesis that combined administration of TGF-b1 and IGF-I in a patellar tendon defect model could enhance the mechanical properties of the healed tendon. Twenty four New Zealand white rabbits were used for this purpose. In each animal, the right knee was used for the application of the growth factors, whereas the left knee served as an untreated control. The growth factors were mixed with fibrin sealant as a delivery vehicle. Two groups of rabbits were sacrificed after 2 weeks and 6 weeks respectively. Application of the growth factors resulted in a significant increase in force at failure, ultimate stress, stiffness, and energy uptake at 2 weeks, whereas none of the parameters revealed any significant difference between the two groups at 6 weeks. This study provides valuable information on the effect of the two growth factors on this patellar tendon defect model.
在髌腱缺损模型中联合给予转化生长因子β1（TGF-b1）和胰岛素样生长因子I（IGF-I）可增强愈合肌腱的力学性能。为此使用了24只新西兰白兔。在每只动物中，右膝用于应用生长因子，而左膝作为未处理的对照。将生长因子与纤维蛋白密封剂混合作为递送载体。两组兔子分别在2周和6周后处死。在2周时，应用生长因子导致破坏时的力、极限应力、刚度和能量吸收显著增加，而在6周时，两组之间的任何参数均未显示出任何显著差异。本研究提供了关于这两种生长因子对该髌腱缺损模型影响的有价值信息。
