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药物递送、再生医学和创新生物支架视角下的肌腱组织修复

Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds.

作者信息

Hafeez Muhammad Nadeem, d'Avanzo Nicola, Russo Valentina, Di Marzio Luisa, Cilurzo Felisa, Paolino Donatella, Fresta Massimo, Barboni Barbara, Santos Hélder A, Celia Christian

机构信息

Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 0001, Finland.

出版信息

Stem Cells Int. 2021 Nov 16;2021:1488829. doi: 10.1155/2021/1488829. eCollection 2021.

DOI:10.1155/2021/1488829
PMID:34824586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8610661/
Abstract

The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these approaches have their own advantages and limitations. Regenerative medicine and tissue engineering are interdisciplinary fields that aspire to develop novel medical devices, innovative bioscaffold, and nanomedicine, by combining different cell sources, biodegradable materials, immune modulators, and nanoparticles for tendon tissue repair. Different studies supported the idea that bioscaffolds can provide an alternative for tendon augmentation with an enormous therapeutic potentiality. However, available data are lacking to allow definitive conclusion on the use of bioscaffolds for tendon regeneration and repairing. In this review, we provide an overview of the current basic understanding and material science in the field of bioscaffolds, nanomedicine, and tissue engineering for tendon repair.

摘要

由于肌腱组织血管少且细胞含量低的特性，其自身的愈合能力有限。到目前为止，人们已经对几种传统的肌腱修复方法进行了测试，以加速愈合过程，但所有这些方法都有各自的优缺点。再生医学和组织工程是跨学科领域，旨在通过结合不同的细胞来源、可生物降解材料、免疫调节剂和纳米颗粒来开发新型医疗设备、创新生物支架和纳米药物，用于肌腱组织修复。不同的研究支持了这样一种观点，即生物支架可为肌腱增强提供一种具有巨大治疗潜力的替代方法。然而，目前缺乏足够的数据来就生物支架在肌腱再生和修复中的应用得出明确结论。在这篇综述中，我们概述了目前在生物支架、纳米医学和组织工程领域用于肌腱修复的基本认识和材料科学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fa/8610661/c3fea6510a61/SCI2021-1488829.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fa/8610661/c3fea6510a61/SCI2021-1488829.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fa/8610661/73a35caa8366/SCI2021-1488829.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fa/8610661/144da91908cb/SCI2021-1488829.005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fa/8610661/c3fea6510a61/SCI2021-1488829.008.jpg

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