Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nano Lett. 2010 Aug 11;10(8):2915-21. doi: 10.1021/nl101046t.
We report on DNA translocations through nanopores created in graphene membranes. Devices consist of 1-5 nm thick graphene membranes with electron-beam sculpted nanopores from 5 to 10 nm in diameter. Due to the thin nature of the graphene membranes, we observe larger blocked currents than for traditional solid-state nanopores. However, ionic current noise levels are several orders of magnitude larger than those for silicon nitride nanopores. These fluctuations are reduced with the atomic-layer deposition of 5 nm of titanium dioxide over the device. Unlike traditional solid-state nanopore materials that are insulating, graphene is an excellent electrical conductor. Use of graphene as a membrane material opens the door to a new class of nanopore devices in which electronic sensing and control are performed directly at the pore.
我们报告了通过在石墨烯膜中创建的纳米孔进行的 DNA 转位。这些器件由 1-5nm 厚的石墨烯膜组成，通过电子束雕刻出直径为 5 到 10nm 的纳米孔。由于石墨烯膜很薄，我们观察到的阻断电流比传统的固态纳米孔大。然而，离子电流噪声水平比氮化硅纳米孔大几个数量级。通过在器件上沉积 5nm 的二氧化钛，可以降低这些波动。与传统的绝缘固态纳米孔材料不同，石墨烯是一种优秀的电导体。将石墨烯用作膜材料为一类新型的纳米孔器件打开了大门，在这类器件中，可以直接在孔处进行电子传感和控制。
